Best Builds Tier List

S-tier builds consistently clear Ascension 20 with multiple paths to assemble the win condition.

Ironclad Strength and Bloodletting builds scale through Demon Form or infinite loops; Offering accelerates both.

Silent Poison and Sly discard dominate; Noxious Fumes bypasses block; Acrobatics and Prepared enable free plays.

Defect Lightning and Frost scale with Defragment and Hot Fix; Electrodynamics provides AoE for multi-enemy fights.

Regent star builds with Glow, Convergence, and Gamma Blast loop effectively; Bombardment one-cards many fights.

Necrobinder Soul builds with Capture Spirit and Haunt outscale; Doom bypasses all defenses when stacked.

Key relics include Vajra, Mummified Hand, Bag of Preparation, and energy boss relics.

Card removal and transforms are essential for small-deck infinites and consistent draw.

A-tier builds are strong but may need specific relic or card combos; they win most runs with good drafting.

Ironclad Barricade requires Barricade, Unmovable, and Impervious; weaker without Feel No Pain and Power Through.

Silent Shiv works but Blade Dance exhausting hurts Accuracy draw order; consider Poison or Sly instead.

Defect Claw has fallen in STS2; Frost and Lightning are more reliable.

Regent Forge is situational; star strategies outperform in most runs.

Necrobinder Doom needs Countdown, Sleight of Flesh, and Death's Door for full value.

Pivot based on boss rewards and shop offerings; don't tunnel on one archetype.

Upgrade key cards at campfires; dodge elites if your deck isn't ready.

Skipping is often the correct play when card rewards don't fit your build or dilute your deck.

Ironclad should skip aggressively after Act 1 once infinite pieces are assembled.

Silent benefits from a lean deck; skip cards that don't enable discard, poison, or draw.

Defect wants Frost, Focus, and orb slots; skip attacks and random powers that don't scale.

Regent skips Forge cards when on star build; skip expensive cards without star synergy.

Necrobinder skips Osty cards when on Soul or Doom; avoid cards that conflict with cycling.

When in doubt, skip—adding a mediocre card hurts more than adding nothing.

Transforms and removes from events are often better than raw card picks.