| Curse of Knowledge | Player must choose: 1st time: gain Mind Rot or 6 Decay; 2nd time: gain Sloth or 7 Decay; 3rd time: gain Wither or 8 Decay. | Player must choose: 1st time: gain Mind Rot or 6 Decay; 2nd time: gain Sloth or 7 Decay; 3rd time: gain Wither or 8 Decay. | Used on the first turn of the cycle, only 3 times total, then skipped in subsequent cycles. |
| Have a Taste | Deal 17 damage. | Deal 18 damage. | Used on the second turn of the cycle. |
| Knowledge Overload | Deal 8x3 damage. | Deal 9x3 damage. | Used on the third turn of the cycle. |
| Ponder | Deal 11 damage, heal 30, gain 2 Strength. | Deal 13 damage, heal 30, gain 3 Strength. | Used on the fourth turn of the cycle. In co-op mode, heal amount is multiplied by number of players. |